Health claim
“Exercising in a fasted state enhances activation of sirtuin genes (e.g., SIRT1) more than exercising after eating.”
Claim checked — strong evidenceLow riskexercise
Evidence Summary
Multiple well-designed studies consistently support this claim.
Research indicates fasting before exercise can increase SIRT1 activity in animal models and some human studies.
Extracted from
How to Exercise to Live Longer | Lifespan with Dr. David Sinclair - S2, Ep. 5David Sinclair
The episode discusses Dr. David Sinclair's perspective on exercise strategies that may support longer, healthier lives, highlighting mechanisms of cellular aging and practical workout recommendations.
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